Fig. 5.

Pro-fibrotic mediators in Tsk-1 model following STAT3 inhibition

Total RNA was isolated from skin biopsies from Pa/Pa control mice treated with DMSO or C188-9 and Tsk-1 mice treated with DMSO or C188-9. RNA transcripts were determined for Col1α1 (A), α-SMA (B), TGF-β (C), CTGF (D), IL-6 (E), Fibronectin (F) and Cad11 (G). Transcripts were measured in parallel with 18S rRNA and values are presented as mean of fold change transcripts ±s.e.m., n = 10–12 mice per group (*P ≤ 0.05 Pa/Pa DMSO vs Tsk-1 DMSO; **P ≤ 0.05 Tsk-1 DMSO vs Tsk-1 C188-9).