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. 2018 Jul 26;10(6):913–921. doi: 10.1080/19420862.2018.1474996

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Figure 4. — Impact of IgG1 antibodies with CRS-inducing potential on NK cells in preclinical whole blood assay. Human whole blood were incubated with anti-CD52, mAb1, mAb2, or mAb3 for 24 h. (A-D) IFN-γ production by NK cells (CD3-CD56+) and (B) NKT cells (CD3+ CD56+) and T cells (CD3+ CD56-) in response to (A,B) anti-CD52, (C,D) mAb1, mAb2 and mAb3. (E-H) Analysis of CD16 expression on NK cells upon stimulation with (E,F) anti-CD52, (G,H) mAb1 and mAb2, or (E-H) mAb3. Bars are presented as mean ± SEM.