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. 2018 Jul 26;10(6):913–921. doi: 10.1080/19420862.2018.1474996

Figure 5.

Figure 5.

Importance of TNF for IFN-γ release in response to IgG1 antibodies with CRS-inducing potential. IFN-γ release expressed in pg/ml was assessed using human whole blood pre-incubated with or without anti-TNF (infliximab) and then stimulated for 24 h with (A) anti-CD52, (B) mAb2, or (C) IgG1 isotype control. (D) IFN-γ release levels from untreated or infliximab treated whole blood. Significant results are denoted by asterisks. P-values generated by one-way ANOVA followed by paired T-test of concentrations of blocked versus control samples, (*p < 0.05). Donor responses shown are n = 7.