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. 2018 Jul 26;10(6):913–921. doi: 10.1080/19420862.2018.1474996

Figure 7.

Figure 7.

FcγRIIIa polymorphisms determine the magnitude of IgG1-dependent IFN-γ secretion. (A,B) 73 donors were grouped by FcγRIIIa polymorphisms: (n = 26 V/F, 19 V/V, 28 F/F). IFN-γ release was assessed using FcγRIIIa-158 genotyped human whole blood stimulated for 24 h with anti-CD52. (C,D) 19 donors were grouped by FcγRIIIa polymorphisms: (n = 6 V/F, 6 V/V, 7 F/F). IFN-γ release was assessed using FcγRIIIA-158 genotyped human whole blood stimulated for 24 h with mAb1. (E,F) 25 donors were grouped by FcγRIIIa polymorphisms (n = 9 V/F, 9 V/V, 7 F/F). IFN-γ release was assessed using FcγRIIIa-158 genotyped human whole blood stimulated for 24 h with mAb2. The median of IFN-γ response for each genotype is denoted by a horizontal bar. (B,D,F) Median and range of IFN-γ response based on FcγRIIIa polymorphisms.