Table 1.

Cytokine release profile of CRS-inducing IgG1 antibodies.

Molecule	Cytokine	Fold change rangea	% responding donorsb
Anti-CD52	IFN-γ	370–1823	100
	IL-6	36–488	100
	TNF	23–166	100
mAb1	IFN-γ	1.0–7.6	50
	IL-6	0.6–1.1	/
	TNF	0.7–1.2	/
mAb2	IFN-γ	3–117	100
	IL-6	0.9–12	16
	TNF	0.8–3.9	33
mAb3	IFN-γ	0.6–1.52	/
	IL-6	0.7–1.56	/
	TNF	0.8–1.59	/

^aFold change is relative to the baseline cytokine levels of the relevant untreated samples. Fold change range shows the minimum and maximum fold change of cytokine detected for all donors analyzed. ^bPercent donor responding was calculated by dividing the number of positive responded donors by donor total number. Positive responding donor has fold change ≥ 2 above the relevant untreated samples. /indicates no positive responding donor.