Table 1.

Structural analysis of HC Asn325 from IgG1 and IgG4 Fc structural models in the PDB.

IgG Type	PDB ID	pH	Resolution	Cγ-N distance (Å)	SASAa (Å2) by MOEb	Chain
IgG1	3AVE	7.0	2.0	3.3	3.07	A
	3V7M	5.1	2.0	3.4	18.98	A
	4BYH	4.0	2.3	3.2	13.99	B
	2DTS	7.0	2.2	3.2	3.93	A
	4DZ8	7.0	1.9	3.5	5.54	A
	3D6G	6.5	2.3	3.4	2.43	A
	4W4O	4.6	1.8	3.2	11.12	A
				3.2	14.28	B
	4W4N	6.1	1.8	3.2	4.26	B
	3SGJ	6.0	2.2	3.3	6.90	A
				3.3	6.80	B
	1L6X	6.0	1.65	3.0	6.20	A
	4B7I	5.5	2.3	3.3	6.89	A
IgG4	4C55	6.5	2.4	4.7	24.2	A
				4.7	14.0	B
	4C54	6.5	1.9	4.7	22.9	A
				4.7	10.9	B
	5W5M	5.5	1.9	4.6	25.5	A
				4.6	27.5	B

^a SASA = Solvent Accessible Surface Area.

^b MOE = Molecular Operating Environment software package.