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The amino acid sequences of the signal peptides encoded in the non-originator cell lines for the light and heavy chains.
A. The signal peptide of the light chain is shown. The red arrow shows the expected cleavage site and the blue arrow shows the alternate cleavage site, resulting in an additional Ser residue on a small proportion of the mAb. B. The signal peptide of the heavy chain is shown. The red arrow shows the expected cleavage site.
