Figure 3. Lack of HIF-1α in the airway epithelium suppresses tumor cell proliferation and angiogenesis.

Representative photomicrographs of immunohistochemically stained lung tissue from CC-LR and LR/HIF-1α^Δ/Δ mice in the absence or presence of NTHi-induced COPD-type airway inflammation at age of 14 weeks for angiogenesis marker, CD31 (A), or proliferation marker, Ki-67 (B) (20× magnification, scale bar = 50 μm, applicable to all panels).