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. 2018 Aug 10;14(11):1898–1910. doi: 10.1080/15548627.2018.1491489

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Figure 1. — The LAMP2A receptor promotes stress resistance and neuroprotection in Drosophila. (a) Starvation resistance. Expression of the human LAMP2A protein in all neurons significantly extended Drosophila survival upon prolonged starvation (elav>LAMP2A flies) compared to elav-Gal4/+ (elav/+) driver and UAS-LAMP2A/+ (LAMP2A/+) effector controls. (b) Paraquat exposure. Survival of elav>LAMP2A flies fed with 20 mM paraquat for 72 h was markedly increased compared to the elav/+ and LAMP2A/+ controls. (c) Effect on age-related locomotor decline. Pan-neuronal LAMP2A expression (elav>LAMP2A flies) significantly delayed age-related decrements in climbing performance (SING assay) compared to driver and effector controls that behaved like the wild type. (d) Lifespan assay. elav/+ and elav>LAMP2A flies showed similar longevity curves (median lifespan 57 and 55 days, respectively) indicating that neuronal LAMP2A expression does not affect Drosophila lifespan.