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. 2018 Aug 10;14(11):1991–2006. doi: 10.1080/15548627.2018.1501132

Figure 4.

Figure 4.

Autophagy deficiency accelerates atherosclerosis and increases maximal external diameter in SMCs of mice fed a Western diet. (A) Representative en face view of the entire aorta of control Atg7f/f:apoeKO mice (Control) and Atg7cKO:apoeKO mice (cKO:KO) fed a Western diet, stained with oil-red O. Scale bars: 5 mm. (B) Oil-red O-positive areas of Control and cKO:KO fed a Western diet. Data are shown as a box plot of 9 mice in each group. *P < 0.05 vs Control. (C) Representative view of the entire aorta of Control and cKO:KO fed either a normal chow diet or a Western diet. The white arrow indicates the suprarenal aorta with an enlarged diameter. Scale bars: 5 mm. (D) Maximal external diameters of the suprarenal aorta of Control and cKO:KO fed a normal chow diet or a Western diet. Data are shown as a box plot of 6 Control and 5 cKO:KO fed a normal chow diet and 20 Control and 30 cKO:KO fed a Western diet. *P < 0.05 vs Control.