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. 2018 Aug 6;14(11):1959–1975. doi: 10.1080/15548627.2018.1493044

Figure 2.

Figure 2.

Trehalose induces thermogenesis in autophagy-deficient Atg16l1HM mice. (A) Dark and light cycle heat generation in wild-type or Atg16l1HM mice fed regular chow diet with either sterile water or 3% trehalose in water ad libitum. (B-D) Oxygen consumption (B), CO2 production (C), and respiratory exchange ratio (RER) (D) in same mice presented in (A); n = 5 mice per group. (E-H) Heat production (E), oxygen consumption (F), CO2 production (G), and RER (H) in wild-type and epg5 null mice treated with or without oral trehalose during dark and light cycles; n = 3–4 mice per group. (I-L) Heat production (I), oxygen consumption (J), CO2 production (K), and RER (L) in wild-type and Becn1+/- mice treated with or without oral trehalose during dark and light cycles; n = 4 mice per group. *P < 0.05, **P < 0.01 and ****P < 0.0001 versus control by Student’s T-test with Bonferroni-Dunn post-hoc correction for multiple tests.