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. 2018 Aug 6;14(11):1959–1975. doi: 10.1080/15548627.2018.1493044

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Figure 8. — Trehalose-induced thermogenesis is partly FGF21-dependent. (A) qPCR analysis of Fgf21 mRNA in epididymal white adipose tissue (eWAT) and liver after scrambled or Fgf21-directed antisense oligonucleotide (ASO) treatment 2 wk prior to trehalose treatment and sacrifice. (B) Hepatic Fgf21 mRNA quantification in livers derived from mice treated with or without trehalose and with or without Fgf21 ASO. (C) Circulating FGF21 peptide quantification by colorimetric ELISA in serum from mice treated with or without trehalose and with or without Fgf21 ASO. (D) Heat generation over time for trehalose-treated mice pre-treated with scrambled or Fgf21-specific antisense oligonucleotide (ASO). (E) Mean areas under the total heat-time curve, or during dark- (1801–0600 h) or light cycles (0601 – 1800 h). * and ****, P < 0.05 and 0.0001 vs. scramble ASO + trehalose by T-test with Bonferroni-Dunn post hoc correction for n = 4 mice per treatment group.