Table 1. List of Seeds Used for Building the FTD-PN and Associated Features.

gene name	frequency (Mendelian%)	pathology	inclusion in PPI network
C9orf72a	common (7–20%)	FTLD-TDP	YES
GRN	common (5–11%)	FTLD-TDP	YES
MAPT	common (2–11%)	FTLD-Tau	YES
ATXN2a	rare (<1%)	SNCA, polyGIn	YES
CHCHD10a	rare (<1%)	FTLD-TDP	NO
CHMP2B	rare (<1%)	FTLD-UPS	YES
DCTN1a	rare (<1%)	not understood; possibly FTLD-TDP	YES
FUSa	rare (<1%)	FTLD-FUS	YES
IFT74a	rare (<1%)	not known; possibly FTLD-TDP	NO
OPTNa	rare (<1%)	FTLD-TDP	YES
SQSTM1a	rare (<1%)	FTLD-TDP	YES
TARDBPa	rare (<1%)	FTLD-TDP	YES
UBQLN2a	rare (<1%)	FTLD-TDP	YES
VCP	rare (<1%)	FTLD-TDP	YES
BTNL2	GWAS	not known	NO
CTSC	GWAS	not known	NO
HLA-DRA	GWAS	not known	YES
HLA-DRB5	GWAS	not known	NO
RAB38	GWAS	not known	NO
TMEM106B	GWAS	FTLD-TDP	NO

^aGenes belonging to the FTD-ALS spectrum; ALS = amyotrophic lateral sclerosis.