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. 2017 Jun 8;22(6):958. doi: 10.3390/molecules22060958

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Scheme 1 — General synthetic route for target compounds. Reagents and conditions: (a) BrCH₂CH₂OH, K₂CO₃, dimethylformamide (DMF), 100 °C, 12 h; (b) i. NaH, DMF, 0–5 °C; ii. 2-fluoropyridine, DMF, 55 °C, 6 h; (c) NH₂OH/NaOH, EtOH/H₂O, r.t.; (d) substituted carboxylic acid, dicyclohexylcarbodiimide (DCC), 4-dimethylaminopyridine (DMAP), dichloromethane (DCM).