Skip to main content
. 2017 Jun 15;22(6):995. doi: 10.3390/molecules22060995

Table 1.

Details of synthesis of N-((5-(Substituted methylene amino)-1,3,4-thiadiazol-2-yl)methyl) benzamide derivatives 7(al) using conventional method and microwave method.

Entry Conventional Method Microwave Method
Solvent Temperature °C Time (h) Yield (%) Time (min) Yield (%)
7a Ethanol 80–90 3.30 78 8 95
7b Ethanol 80–90 5.10 77 12 92
7c Ethanol 80–90 5.00 78 12 94
7d Ethanol 80–90 7.20 66 15 94
7e Ethanol 80–90 7.25 52 15 92
7f Ethanol 80–90 8.00 48 18 92
7g Ethanol 80–90 5.25 76 12 95
7h Ethanol 80–90 7.30 66 15 88
7i Ethanol 80–90 8.00 68 20 86
7j Ethanol 80–90 8.00 48 20 88
7k Ethanol 80–90 4.15 44 10 85
7l Ethanol 80–90 4.25 56 10 84