Table 1.
IC50 values of the AChE and BChE inhibitory effects of adamantyl-based compounds.
| Compounds | Substituent | AChE IC50 (µM) | BChE IC50 (µM) |
|---|---|---|---|
| 2a | benzene | 994.26 ± 19.35 | >1500 |
| 2b | 2-chlorobenzene | 360.56 ± 30.05 | >1500 |
| 2c | 3-chlorobenzene | 280.43 ± 17.35 | 971.50 ± 62.55 |
| 2d | 4-chlorobenzene | 340.52 ± 34.69 | 1291.99 ± 30.05 |
| 2e | 2,4-dichlorobenzene | 77.15 ± 7.86 | 306.77 ± 25.15 |
| 2f | 2-methybenzene | 174.98 ± 25.87 | >1500 |
| 2g | 3-methybenzene | 190.99 ± 14.43 | >1500 |
| 2h | 4-methybenzene | >1500 | >1500 |
| 2i | 2-methoxybenzene | >1500 | >1500 |
| 2j | 3-methoxybenzene | 166.46 ± 19.58 | 223.30 ± 17.58 |
| 2k | 4-methoxybenzene | >1500 | >1500 |
| 2l | 2-nitrobenzene | 689.23 ± 44.48 | >1500 |
| 2m | 3-nitrobenzene | 232.98 ± 25.88 | >1500 |
| 2n | 4-nitrobenzene | 349.47 ± 25.22 | 776.59 ± 33.63 |
| 2o | 2-aminobenzene | >1500 | >1500 |
| 2p | 3-aminobenzene | >1500 | >1500 |
| 2q | 4-aminobenzene | >1500 | >1500 |
| 2r | 2-pyridine | >1500 | >1500 |
| Tacrine | 0.21 ± 0.04 | 0.06 ± 0.01 |
Note: AChE represents Acetylcholinesterase and BChE represents Butyrylcholinesterase.