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. 2017 Jun 16;22(6):1001. doi: 10.3390/molecules22061001

Table 1.

Anti-Mycobacterium tuberculosis H37Rv activities of indeno[1,2-c]quinoline derivatives. Results expressed as minimum inhibitory concentration (MIC) compared to isoniazid (INH).

Compounds R1 R2 MIC (μg/ mL) Survival Rate of Vero Cells @ 20 μg/mL (%)
3a H graphic file with name molecules-22-01001-i001.jpg 4.56 88.61
3b H graphic file with name molecules-22-01001-i002.jpg 4.93 96.18
3c H graphic file with name molecules-22-01001-i003.jpg 3.12 91.19
3d H graphic file with name molecules-22-01001-i004.jpg 2.09 91.23
3e H graphic file with name molecules-22-01001-i005.jpg 4.97 87.78
3f H graphic file with name molecules-22-01001-i006.jpg 3.98 91.11
3g H graphic file with name molecules-22-01001-i007.jpg 3.07 92.25
4a OMe graphic file with name molecules-22-01001-i001.jpg 17 89.62
4b OMe graphic file with name molecules-22-01001-i002.jpg >20 99.55
4c OMe graphic file with name molecules-22-01001-i003.jpg >20 94.47
4d OMe graphic file with name molecules-22-01001-i004.jpg 7.74 84.72
4e OMe graphic file with name molecules-22-01001-i005.jpg 19.10 87.59
4f OMe graphic file with name molecules-22-01001-i006.jpg >20 90.26
4g OMe graphic file with name molecules-22-01001-i007.jpg >20 87.60
5 18.0 85.41
6 >20 89.83
7 >20 84.14
8 >20 91.48
9 >20 81.20
10 >20 80.28
11 1.98 89.55
12 0.96 94.25
INH 0.8–1.2 84.80