Table 2.
Anti-inflammatory activities of indeno[1,2-c]quinoline derivatives in formyl-Lmethionyl-l-leucyl-l-phenylalanine (fMLF)-activated human neutrophils (IC50 in μM) a.
| Compounds | Superoxide Anion | Elastase Release |
|---|---|---|
| 3a | >10 | >10 |
| 3b | >10 | >10 |
| 3c | >10 | >10 |
| 3d | 1.78 ± 0.44 | 2.20 ± 0.69 |
| 3e | 2.90 ± 0.11 | 2.80 ± 0.09 |
| 3f | 3.37 ± 0.17 | 4.50 ± 1.32 |
| 3g | 2.77 ± 0.47 | 2.12 ± 1.19 |
| 4a | >10 | >10 |
| 4b | >10 | >10 |
| 4c | >10 | >10 |
| 4d | 2.82 ± 0.30 | 2.05 ± 0.24 |
| 4e | 1.89 ± 0.65 | 2.93 ± 0.70 |
| 4f | 1.93 ± 0.92 | 0.88 ± 0.30 |
| 4g | 0.68 ± 0.14 | 0.46 ± 0.08 |
| 5 | 4.02 ± 1.08 | 5.29 ± 0.48 |
| 6 | >10 | >10 |
| 7 | 0.83 ± 0.47 | 1.39 ± 0.64 |
| 8 | 2.68 ± 0.95 | 2.13 ± 0.92 |
| 9 | 3.64 ± 1.43 | >10 |
| 10 | 2.41 ± 0.36 | >10 |
| 11 | 1.67 ± 0.87 | >10 |
| 12 | 1.72 ± 0.23 | 1.76 ± 0.49 |
| LY294002 b | 1.36 ± 0.33 | 2.21 ± 0.45 |
a Concentration necessary for 50% inhibition (IC50); Results are presented as mean ± SEM (n = 3). b LY294002 (a phosphatidylinositol-3-kinase inhibitor) was used as a positive control for superoxide anion generation and elastase release.