Scheme 1.
Synthesis of the GA amino alkyl derivatives 1–11. Reagents and conditions: (a) K2CO3,CH3I, DMF, 24 h, 25 °C; (b) ClCH2COCl, Et3N, THF (or CH2Cl2), 25 °C, 12 h; (c) H2N-(CH2)n-NH2, DMF, K2CO3, 12 h, 25 °C.
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