Table 9.
Cytotoxicity (IC50 values in μM) of 80–95, 97 in a panel of various cancer cell lines.
| Compound | 518A2 | 8505C | A2780 | A549 | DLD-1 | LIPO | MCF-7 | SW1736 |
|---|---|---|---|---|---|---|---|---|
| 80–85 | >30 | >30 | >30 | >30 | >30 | >30 | >30 | >30 |
| 86 | 18.33 | 19.28 | 28.83 | >30 | >30 | 28.74 | 21.87 | 16.56 |
| 87 | 29.82 | 27.69 | 14.84 | 26.62 | 29.56 | 24.80 | 28.68 | 27.00 |
| 88 | >30 | >30 | >30 | >30 | >30 | >30 | >30 | 13.24 |
| 89 | >30 | 29.42 | >30 | >30 | >30 | >30 | >30 | 29.40 |
| 90–92 | >30 | >30 | >30 | >30 | >30 | >30 | >30 | >30 |
| 93 | >30 | >30 | 14.95 | >30 | >30 | >30 | >30 | 19.14 |
| 94, 95 | >30 | >30 | >30 | >30 | >30 | >30 | >30 | >30 |
| 97 | 23.69 | 24.30 | 10.39 | >30 | >30 | 25.52 | >30 | 16.98 |