Table 12.

Cytotoxicity (IC₅₀ values in μM) of 116–130 in a panel of various cancer cell lines.

Compound	A549	SKMEL	T98G	HS683	U373	PC3	MCF7	816F10
GA	>100	92	85	84	83	80	76	37
116	52	>100	91	59	43	34	34	37
117	40	>100	>100	57	75	43	38	31
118	33	82	46	56	42	33	31	32
119	43	60	73	63	57	41	37	48
120	31	>100	>100	58	32	31	59	30
121	47	49	62	38	55	53	28	36
122	63	42	77	58	75	72	46	31
123	37	38	54	36	37	47	30	31
124	68	35	77	67	76	72	27	31
125	28	37	35	31	29	30	25	28
126	29	49	30	28	30	32	28	31
127	7	9	12	6	6	8	4	4
128	29	65	71	42	42	46	42	41
129	31	38	25	8	29	9	30	34
130	38	33	35	36	35	39	30	33