Table 15.
Cytotoxicity (IC50 values in μM) of 167–175 in a panel of various cancer cell lines.
| Compound | 518A2 | 8505C | A253 | A549 | DLD-1 | Lipo | SW1736 |
|---|---|---|---|---|---|---|---|
| GA | 83.92 | 86.50 | 80.78 | 82.76 | 81.21 | 81.44 | 76.93 |
| 167 | >30 | >30 | >30 | >30 | >30 | >30 | >30 |
| 168 | >30 | >30 | >30 | >30 | >30 | ＞30 | >30 |
| 169 | >30 | >30 | >30 | >30 | >30 | >30 | >30 |
| 170 | 15.19 | 15.59 | 15.89 | 20.27 | 22.98 | 15.46 | 19.87 |
| 171 | 28.99 | >30 | >30 | >30 | >30 | >30 | 28.64 |
| 172 | 21.00 | 8.82 | 10.97 | 4.28 | 23.09 | 11.47 | 1.88 |
| 173 | 14.91 | 11.61 | 13.57 | 19.16 | 14.88 | 12.77 | 16.36 |
| 174 | 15.33 | 15.59 | 15.89 | 20.27 | 22.98 | 15.46 | 19.87 |
| 175 | >30 | >30 | >30 | >30 | >30 | >30 | >30 |