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. 2017 Jun 12;22(6):977. doi: 10.3390/molecules22060977

Scheme 16.

Scheme 16

Preparation of difluoromethyl 5-aminopyrazoles- and isoxazoles. a 19F-NMR yield using PhF as internal standard. b isolated yield. c 40 °C, 18 h. DIPEA, N,N-diisopropylethylamine.