Table 2.
Effect produced by the extract and fractions obtained from Serjania schiedeana on auricular edema induced by TPA (2.5 μg/20 μL) in mice.
| Treatment | Doses (mg/Ear) |
Edema (mg) Mean ± SEM |
Edema Inhibition (%) | Pharmacologic Parameters |
|---|---|---|---|---|
| SsEtOAc | 2.0 | 1.02 ± 0.71 * | 90.09 | |
| F-6 | 1.0 | 2.94 ± 0.34 * | 71.68 | |
| F-12 | 2.24 ± 0.70 * | 78.42 | ||
| F-13 | 3.40 ± 1.0 * | 67.24 | ||
| F-14 | 1.04 ± 0.22 * | 89.95 | ||
| ETP | 0.125 | 7.9 ± 1.01 | 23.5 | ED50 = 0.25 mg/ear Emax = 52.9% |
| 0.25 | 7.6 ± 0.73 | 26.46 | ||
| 0.5 | 7.5 ± 0.89 | 27.74 | ||
| 1.0 | 5.5 ± 1.39 * | 47.01 | ||
| 2.0 | 2.8 ± 0.93 * | 72.22 | ||
| IND | 1.0 | 1.2 ± 0.4 * | 88.25 | |
| VEH | ---- | 10.3 ±1.46 | ---- |
Analysis of variance (ANOVA) with post hoc Bonferroni (n = 8; mean ± SD). * p < 0.05 in comparison with VEH group (TPA).