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Enzymatic activities and LibDock score of 8–12 and sunitinib.
| Compd. | R | % Inhibition at 50 nM | IC50 (nM) | % Inhibition of Aurora A at 1.0 μM | LibDock Score of VEGFR-2 Binding | ||
|---|---|---|---|---|---|---|---|
| VEGFR-2 | PDGFRβ | VEGFR-2 | PDGFRβ | ||||
| Sunitinib | - | 29 | 44 | 140.0 | 61.4 | 50.7 | 110.303 |
| 8 | -H | 56 | 64 | 30.2 | 22.4 | 95.9 | 134.754 |
| 9 | -F | 35 | 36 | 110.7 | 97.5 | 93.1 | 137.901 |
| 10 | -Cl | 58 | 64 | 35.0 | 24.9 | 93.7 | 130.921 |
| 11 | -Br | 64 | 68 | 24.7 | 16.1 | 93.1 | 129.433 |
| 12 | -I | 58 | 62 | 35.1 | 29.3 | 92.9 | 125.031 |
