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. 2018 Sep 1;34(7):489–499. doi: 10.1089/jop.2017.0131

FIG. 3.

FIG. 3.

Systemic administration of PAM increased the number of Iba-1+ cells in the subretinal space, over the CNV lesion, and increased neutrophil infiltration into the CNV lesion after laser injury. Representative 5 × image of a mouse PEC 7 days after laser injury in mice injected with (A) Vehicle or (B) PAM. (C) Bar graph and (D) Dot plot from a study demonstrating the number of Iba1+ cells in mice injected with PAM (n = 8–10 eyes of 4–5 mice per condition, P < 0.05). (E) Bar graph and (F) Dot plot of mean intensity of Iba1+ label on CNV lesions (n = 8–10 eyes, 20–29 CNV analyzed per condition, P < 0.01). 20 × images of CNV labeled with GR1 from mice treated with PBS (G) or PAM (H) Collected 3 days after laser. (I) Bar graph and (J) Dot plot of number of GR1+ neutrophils per CNV lesion (P < 0.001 at day 3, > 0.05 at day 7). Scale bar (A) and (B) 500 μm and (G) and (H) 200 μm. Statistics performed with an unpaired t-test. ONH, optic nerve head (arrow).