FIG. 4.

TLR-2 genetic deletion abrogates the effect of PAM on CNV area growth. (A) and (C) Bar graph shows mean area of CNV ± SEM and (B) and (D) Dot plot of data from 2 independent experiments evaluating area of CNV in TLR-2 KO mice with littermate sex-matched wild-type controls. One study was with females (A) and 1 with males (C). Mice were injected i.p. with 50 μg of PAM or with water (n = 9–13 mice, 18–26 eyes, 54–78 CNV area analyzed/condition). Statistics assessed with an unpaired t-test. P > 0.05. WT, wild type.