Table 3. Comparison of NDO-LID Rapid Test, M. leprae antigen-specific ELISA and WBA positive response rates.
Leprosy classification | Rapid Test | ELISA (OD) | IFN-γ Secretion by WBA (pg/ml) | |||||||
---|---|---|---|---|---|---|---|---|---|---|
NDO-LID | LID-1 | NDO-LID | ND-O-BSA | LID-1 | ML89 | ML2044 | ML2028 | |||
Cut offα | - | 0.2 | 0.2 | 0.2 | Cut offβ | 50 | 50 | 50 | 50 | |
Total (n) | n (%) | n (%) | n (%) | n (%) | Total (n) | n (%) | n (%) | n (%) | n (%) | |
MB | 38 | 36 (94.7%) | 35(92.1%) | 35(92.1%) | 34(89.5%) | 35 | 14/35 (40%) | 10/35 (28.6%) | 11/35 (31.4%) | 11/35 (31.4%) |
PB | 23 | 15 (65.2%) | 12(52.2%) | 11(47.8%) | 14(60.9%) | 23 | 13 (56.5%) | 11 (47.8%) | 14 (60.7%) | 11 (47.8%) |
Post-MDT | 22 | 7 (31.8%) | 9(45.0%) | 9(45.0%) | 11(55.0%) | 20 | 12/20 (54.5%) | 14/20 (63.6%) | 7/20 (31.8%) | 9/20 (40.9%) |
HHC | 119 | 34 (28.6%) | 53(44.5%) | 31(26.0%) | 63(52.9%) | 116 | 56/116 (48.3%) | 51/116 (44.0%) | 49/115 (42.6%) | 40/116 (34.5%) |
TB | 11 | 1 (9.1%) | 2(18.2%) | 0 | 2(18.2%) | 11 | 0 | 0 | 0 | 0 |
EC | 31 | 10 (33.3%) | 4(12.9%) | 5(16.1%) | 12(38.7%) | 31 | 16 (51.6%) | 15 (48.4%) | 13 (41.9%) | 8 (25.8%) |
α: Cut off value of M. leprae-specific antigen ELISA was defined as 0.2 OD value.
β: Cut off value of IFN-γ was defined as 50 pg/ml.