Table 6. ROC of the diagnostic potential of OD detected in M. leprae antigen-specific ELISA for leprosy diagnosis.

M. leprae Antigens	Subgroups of Cases		p value	AUC	Sensitivity (%)	Specificity (%)	Youden's Index
LID-1	MB vs	PB	0.0007	0.7603	39.13%	94.74%	0.3387
		post MDT	<0.0001	0.823	35.00%	97.37%	0.3237
		HHC	<0.0001	0.8505	50.42%	94.74%	0.4516
		TB	0.0001	0.8804	54.55%	94.74%	0.4929
		EC	<0.0001	0.9334	51.61%	97.37%	0.4898
	PB vs	EC	0.0020	0.7482	41.94%	95.65%	0.3759
	HHC vs	EC	0.0050	0.6641	6.46%	99.16%	0.0562
	TB vs	EC	0.0468	0.7038	58.06%	90.91%	0.4897
NDO-LID	MB vs	PB	0.0001	0.7929	34.78%	97.37%	0.3215
		post MDT	<0.0001	0.8895	30.00%	97.37%	0.2737
		HHC	<0.0001	0.9285	38.66%	97.37%	0.3603
		TB	<0.0001	0.9653	72.73%	97.37%	0.7010
		EC	<0.0001	0.9423	38.71%	97.37%	0.3608
	PB vs	HHC	0.0377	0.6372	13.45%	91.30%	0.0475
		TB	0.0037	0.8123	36.36%	95.65%	0.3201
		EC	0.0366	0.6676	29.03%	91.30%	0.2033
	post-MDT vs	HHC	0.0329	0.6494	20.17%	95.00%	0.1517
		TB	0.0023	0.8364	36.36%	95.00%	0.3136
		EC	0.0186	0.6968	29.03%	95.00%	0.2403
	HHC vs	TB	0.0091	0.7383	36.36%	86.55%	0.2291
	TB vs	EC	0.0257	0.7287	58.06%	90.91%	0.4897
ND-O-BSA	MB vs	PB	0.0022	0.7357	56.52%	86.84%	0.4336
		post MDT	<0.0001	0.8434	20.00%	97.37%	0.1737
		HHC	<0.0001	0.8430	15.97%	97.37%	0.1334
		TB	<0.0001	0.9414	36.36%	97.37%	0.3373
		EC	<0.0001	0.8862	22.58%	97.37%	0.1995
	PB vs	TB	0.0005	0.8755	63.64%	95.65%	0.5929
		EC	0.0205	0.6858	25.81%	95.65%	0.2146
	post-MDT vs	TB	0.0105	0.7818	36.36%	95.00%	0.3136
	HHC vs	TB	0.0017	0.7861	18.18%	99.16%	0.1734
	TB vs	EC	0.0308	0.7214	38.71%	90.91%	0.2962

All of the analytes that showed significant differences (p<0.05) between leprosy and non-leprosy controls according to receiver operating characteristic (ROC) analysis are shown. Sensitivity and specificity were selected based on Youden’s index. AUC = Area under the receiver operator characteristic curve.