Table 8. ROC of the diagnostic potential of IFN-γ detected in overnight culture supernatant for leprosy.
| Subgroups of Cases | IFN-γ/M.leprae Antigens | p value | AUC | Sensitivity (%) | Specificity (%) | Youden's Index |
|---|---|---|---|---|---|---|
| MB vs EC | IFN-γ/ML89 | 0.0204 | 0.6664 | 67.74% | 68.57% | 0.3631 |
| PB vs TB | IFN-γ/ML2044 | 0.0176 | 0.7549 | 90.91% | 69.57% | 0.6048 |
| IFN-γ/ML2028 | 0.0272 | 0.7372 | 81.82% | 73.91% | 0.5573 | |
| post-MDT vs TB | IFN-γ/LID-1 | 0.0020 | 0.8347 | 81.82% | 86.36% | 0.6818 |
| HHC vs TB | IFN-γ/LID-1 | 0.0449 | 0.6834 | 81.82% | 68.97% | 0.5079 |
| EC vs TB | IFN-γ/ML89 | 0.0017 | 0.8211 | 80.65% | 90.91% | 0.7156 |
| IFN-γ/ML2028 | 0.0021 | 0.8152 | 74.19% | 90.91% | 0.651 | |
| IFN-γ/ML2044 | 0.0058 | 0.783 | 70.97% | 90.91% | 0.6188 | |
| IFN-γ/LID-1 | 0.0213 | 0.7361 | 61.29% | 90.91% | 0.522 |
All of the analytes that showed significant differences (p<0.05) between leprosy and uninfected controls according to ROC analysis are shown. Sensitivity and specificity were selected based on Youden’s index. AUC = Area under the receiver operator characteristics curve.