Table 1. Characteristics of HS domains recognized by anti-heparan sulfate (HS) scFv antibodies.

Antibody	VH—CDR3*	HS modifications required for antibody binding:	References
AO4B08	SLRMNGWRAHQ	N-sulfation, 6-O sulfation, 2-O sulfation, C5-epimerization	[28]
EW3D10	GRTVGRN	N-sulfation, 6-O sulfation	[30]
EW4G2	GKVKLPN	N-sulfation, 6-O sulfation, Glucuronic acid	[30]
HS4C3	GRRLKD	N-sulfation, 6-O sulfation, 3-O sulfation, 2-O sulfation	[31]
HS3A8	GMRPRL	N-sulfation, 6-O sulfation, 2-O sulfation, C5-epimerization	[28]
HS4E4	HAPLRNTRTNT	N-sulfation, N-acetylation, C5-epimerization	[28]
LKIV69	GSRSSR	N-sulfation, 2-O sulfation, C5-epimerization	[32]
RB4Ea12	RRYALDY	N-sulfation, N-acetylation, 6-O sulfation	[28]
EV3C3	GYRPRF	N-sulfation, 2-O-sulfation, C5-epimerization	[28]

*Given are the amino acid sequences of the heavy chain variable region complementarity-determining region 3 (VH—CDR3).