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. Author manuscript; available in PMC: 2019 Mar 15.
Published in final edited form as: Coord Chem Rev. 2018 Sep 15;375:38–55. doi: 10.1016/j.ccr.2018.04.007

Table 3. Compilation of electrochemical studies of Cu-Aβ and Cu-αSyn complexes.

Peptide Complex Redox Potential (V) [NHE]† Experimental Conditions Ref.
Electrolyte Solution Electrode Scan Rate (mV/s) Cu:peptide ratio‡
Cu-Aβ1-42 E° ~ 0.500–0.550 [0.699 – 0.749]
(quasi-reversible)		 PB pH 7.3 Ag/AgCl (1M KCl)
(indium/tinoxide working electrode)		 - 1:6
(17 μM)		 [212]
Cu-Aβ1-16 Epa = 0.340
Epc = 0.650		 Tris/HCl pH 7.4,
100 mM NaCl		 NHE - 1:1
(1 mM)		 [200]
Cu-Aβ1-28 Epa = 0.330
Epc = 0.630		 Tris/HCl pH 7.4,
100 mM NaCl		 NHE - 1:1
(1 mM)		 [200]
Cu-Aβ1-16 Epa = 0.780 [0.979]
Epc = 0.085 [0.284]		 PB 5 mM pH 7.4,
0.1M Na2SO4
10% DMSO		 Ag/AgCl 20 1:1
(50 μM)		 [213]
Cu-Aβ1-42 Epa = 0.600 [0.799]
Epc ~ 0.020 [0.219]		 PB 5 mM,
pH 7.4,
0.1M Na2SO4
10% DMSO		 Ag/AgCl 20 1:1
(50 μM)		 [213]
Cu-Aβ1-40 E° = 0.100 [0.299] KCl 0.2 M,
pH 6.9		 Ag/AgCl 50 1:1 [214]
Cu-Aβ1-16 0.300 vs (NHE)
(In-between state)		 PIPES buffer 25 mM,
pH 6.7,
0.2 M KCl		 SCE 20, 50, 100 1:5
(0.2 mM)		 [208]
Cu-Aβ1-16 Epc = -0.076 [0.123]
Epa =-0.140 [0.059]
E°= 0.032 [0.231]
(pH 6.5, mainly Component I)
E° = -0.376 [-0.177]
(pH 8.5, mainly Component II)		 PB 10 mM,
50 mM Na2SO4 		Ag/AgCl 5 1:4
(100 μM)		 [215]
Cu-Ac-Aβ1-16 E°=0.060 [0.259]
(pH 7.4, mainly Component I)
E° = -0.353 [-0.154]
(pH 9.5, Component II)		 PB 10 mM,
50 mM Na2SO4 		Ag/AgCl 5 1:4
(100 μM)		 [215]
Cu-Aβ1-16 Epa - Epc = 0.450 [0.649] KNO3 96 mM
HNO3 4 mM
pH 7.4		 Ag/AgCl 20, 100 0.9:1
(0.45 mM)		 [216]
Cu-Aβ4-16 Epa = 0.830 [1.029] KNO3 96 mM
HNO3 4 mM
pH 7.4		 Ag/AgCl 20, 100 0.9:1
(0.45 mM)		 [216]
Cu-αSyn1-140 0.018 [0.217]
(quasi-reversible)		 PB 5 mM pH 7.4,
0.1 M
Na2SO4 		Ag/ AgCl 5 1:2
(50 μM)		 [217]
Cu-αSyn1-19 0.053 [0.252]
(quasi-reversible)		 PB 5 mM pH
7.4, 0.1 M
Na2SO4 		Ag/ AgCl 5 1:2
(50 μM)		 [217]
Cu-αSyn1-6 Epc (1) ≈ −0.365 [-0.166]
Epc(2) = −0.461 [-0.262]
Epa (1) ≈ −0.101 [0.098]
Epa (2) = −0.024 [0.175]		 PB 10 mM
pH 7.4, 50
mM Na2SO4 		Ag/ AgCl 5 1:1
(300 μM)		 [209]
*

All the redox potential values were obtained using a glassy carbon working electrode unless otherwise stated.

†

Conversion value for the Ag/AgCl electrode to NHE obtained from [218].

‡

Cu concentration is indicated in parenthesis.