(A) Schematic of normal and perturbed protein complex biogenesis.
(B) Fitness profiles for genes encoding subunits of five different protein complexes screened in the CRIPSR-Cas9 fitness dataset, annotated by their gene name abbreviations and cellular localization. Both rows (genes) and columns (cell lines) are hierarchically clustered.
(C) Graphical representation of RNAi- and CRISPR-Cas9-based screening datasets and analysis pipelines (n=501 and n=342 cell lines, respectively; Project Achilles, Broad Institute).