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. Author manuscript; available in PMC: 2018 Sep 24.
Published in final edited form as: Cell Syst. 2018 May 16;6(5):555–568.e7. doi: 10.1016/j.cels.2018.04.011

Figure 1. Genes encoding protein complex subunits display coordinated fitness variation across genetic screens performed in human cancer cell lines.

Figure 1

(A) Schematic of normal and perturbed protein complex biogenesis.

(B) Fitness profiles for genes encoding subunits of five different protein complexes screened in the CRIPSR-Cas9 fitness dataset, annotated by their gene name abbreviations and cellular localization. Both rows (genes) and columns (cell lines) are hierarchically clustered.

(C) Graphical representation of RNAi- and CRISPR-Cas9-based screening datasets and analysis pipelines (n=501 and n=342 cell lines, respectively; Project Achilles, Broad Institute).