Fig 1. Screening of adrenergic receptor antagonists for CXCR4 and ACKR3 agonist activity in PRESTO-Tango β-arrestin recruitment assays.

Data are mean ± SE from n = 4 independent experiments (in triplicates). Cells were stimulated with vehicle, 100 μM of individual AR antagonists or with 200 nM of CXCL12. Luminescence signals are expressed as fold of vehicle-treated cells (control, = 1). *: p<0.05 vs. vehicle (unstimulated). A. CXCR4 PRESTO-Tango assays. B. ACKR3 PRESTO-Tango assays.