Fig 5. Inhibitory effects of polyphenols on ATP/P2X7R-mediated Ca²⁺ influx.

(A) J774.1 cells were pre-treated with each polyphenol (50 μM) or BBG (2 μM) for 10 min followed by ATP stimulation (2 mM) for 10 min. Relative Fluo 4 fluorescence intensities (%) to control (stimulated with ATP alone) were calculated. Data for polyphenols that exhibited inhibitory effects (below 100%) are shown in the graph. (B) Dose-dependent inhibition of ATP-induced Ca²⁺ influx by baicalein (left) and resveratrol (right). Chemical structures of baicalein and resveratrol are also illustrated. All the data represent means ± S.D. of triplicate determinations (*P < 0.05 vs control).