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. 2018 Sep 24;13(9):e0204229. doi: 10.1371/journal.pone.0204229

Fig 6. Anti-inflammatory effects of baicalein through interfering ATP/P2X7R signaling.

Fig 6

(A) Dose-dependent effects of baicalein and resveratrol on LPS/ATP-induced NO production. Cells were pre-treated with each polyphenol for 1 h followed by LPS/ATP stimulation for 24 h (*P < 0.05 vs. LPS group and **P < 0.05 vs. LPS + ATP group). (B) Effects of baicalein and resveratrol (10 μM pre-treatment for 1 h) on LPS/ATP-induced IFN-β mRNA expression 3 h after stimulation (*P < 0.05). (C) Effects of baicalein and resveratrol on ATP-triggered IL-1β secretion in LPS-stimulated J774.1 cells. Cells were treated with LPS (1 μg/ml) for 4 h followed by the addition of ATP (5 mM). Each polyphenol (50 μM) or BBG (10 μM) was added 30 min before the ATP treatment (*P < 0.05). All the data represent means ± S.D. of triplicate determinations.