Table 1.

Antidiabetic drug and their effect on epicardial adipose tissue

Antidiabetic drug	Effect on epicardial adipose tissue
Biguanides	No effect/Possible synergistic effect with DPP-4 and/or GLP-1[39,40]
Alpha-Glucosidase Inhibitors	Lack of data concerning the effect of this class
Thiazolidinediones	Decreased inflammatory cytokine release and thickness of EAT (pioglitazone) modulation of cellular hormonal profile (rosiglitazone)[49,50]
Dipeptidyl peptidase-4 inhibitors	Reduction of EAT thickness (sitagliptin)[39]
Glucagon-like peptide-1 receptor agonists	Reduction of EAT thickness (liraglutide and exenatide)[40,60]
Sodium-glucose cotransporter 2 inhibitors	Reduction of EAT thickness (luseogliflozin, ipragliflozin, canagliflozin, dapagliflozin) and inflammation (luseogliflozin, ipragliflozin, dapagliflozin)[63-67]