Table 5.
Efficacy and potency of agonists acting at RXFP4
| Time point | INSL5 | Analogue 13 | |
|---|---|---|---|
| E max (% forskolin) (bottom) | 10 minutes | 56.16 ± 3.92 | 65.51 ± 4.01 |
| 45 minutes | 40.42 ± 5.91 | 56.52 ± 7.49 | |
| pEC50 | 10 minutes | 8.05 ± 0.17 | 7.55 ± 0.28 |
| 45 minutes | 8.58 ± 0.16 | 7.75 ± 0.49 |
CHO‐RXFP4 cells were stimulated with agonist for 45 minutes, with addition of forskolin 4 minutes after agonist addition. The efficacy (E max) and potency (pEC50) were determined at 10 and 45 minutes. Efficacy is expressed as a percentage of the response to forskolin (10 μmol L−1). Data represent mean ± SEM of three independent experiments.