Table 4.
GnRH neuron excitability parameters and AP kinetics for saline and KA-injected males
| Parameters | Saline | KA |
|---|---|---|
| AP threshold (mV) | -40.6 + 2.9 | -42.3 + 2.3 |
| Input resistance (MΩ) | 745.6 + 36.9 | 1892.2 + 984.2 |
| Capacitance (pF) | 16.7 + 1.0 | 15.7 + 1.0 |
| τ (ms) | 51.0 + 3.7 | 61.7 + 6.5 |
| Latency to firing (ms) | 628.1 + 67.2 | 493.5 + 68.6 |
| ISI first 10 spikes (ms) | 123.4 + 5.4 | 121.4 + 3.7 |
| Ins. freq. first 10 spikes (Hz) | 9.9 + 1.2 | 9.9 + 0.5 |
| FWHM (ms) | 2.3 + 0.12 | 2.4 + 0.3 |
| AHP | 31.6 + 2.6 | 32.8 + 1.9 |
| Time to AHP | 3.6 + 0.1 | 3.5 + 0.2 |
| Max rise slope | 187.3 + 11.7 | 158.9 + 3.2 |
| Max decay slope | -77.5 + 5.1 | -75.3 + 4.2 |
ISI first 10 spikes: average ISI of the first 10 evoked spikes; Ins. freq. first 10 spikes, average instantaneous frequency of the first 10 evoked spikes; FWHM, full-width at half-maximum; AHP, afterhyperpolarization; time to AHP, time between the AP initiation and the peak of AHP. Two-sample t tests for each parameter did not identify any differences between controls and KA-injected groups.