Table 2.
Alterations of white matter tracts for each DTI metric (FA and MD) in sv-PPA, lv-PPA and nfv-PPA compared to healthy controls.
| Tracts | HC | sv-PPA | lv-PPA | nfv-PPA |
|---|---|---|---|---|
| RESULTS FOR FA | ||||
| L-ILF | 0.372 | 0.348 (p = 1, T = −1.53) | 0.358 (p = 1, T = −1.00) | 0.357 (p = 1, T = −0.62) |
| R-ILF | 0.402 | 0.384 (p = 1, T = −1.16) | 0.392 (p = 1, T = −0.43) | 0.396 (p = 1, T = −0.14) |
| L-SLF | 0.377 | 0.340 (p = 0.0085, T = −3.81) | 0.338 (p = 0.0225, T = −3.59) | 0.343 (p = 0.81, T = −2.21) |
| R-SLF | 0.405 | 0.371 (p = 0.19, T = −2.72) | 0.370 (p = 0.143, T = −2.89) | 0.376 (p = 1, T = −1.72) |
| L-TP-SLF | 0.470 | 0.424 (p = 0.12, T = −2.89) | 0.398 (p = 0.0273, T = −3.52) | 0.455 (p = 1, T = −0.28) |
| R-TP-SLF | 0.478 | 0.438 (p = 0.51, T = −2.32) | 0.463 (p = 1, T = 0.19) | 0.492 (p = 1, T = 1.93) |
| L-UF | 0.363 | 0.283 (p = 8.96e−05, T = −5.20) | 0.325 (p = 0.36, T = −2.51) | 0.321 (p = 0.92, T = −2.15) |
| R-UF | 0.391 | 0.318 (p = 0.0060, T = −3.92) | 0.376 (p = 1, T = −0.78) | 0.354 (p = 1, T = −1.74) |
| L-IFOF | 0.435 | 0.384 (p = 0.0182, T = −3.56) | 0.392 (p = 0.0103, T = −3.87) | 0.424 (p = 1, T = −0.50) |
| R-IFOF | 0.437 | 0.401 (p = 0.075, T = −3.07) | 0.407 (p = 0.302, T = −2.58) | 0.424 (p = 1, T = −0.59) |
| L-ATR | 0.375 | 0.340 (p = 0.35, T = −2.47) | 0.344 (p = 0.0955, T = −3.05) | 0.353 (p = 1, T = −1.26) |
| R-ATR | 0.356 | 0.325 (p = 0.0147, T = −3.63) | 0.325 (p = 0.156, T = −2.85) | 0.316 (p = 0.94, T = −2.14) |
| FM | 0.529 | 0.510 (p = 1, T = −0.91) | 0.470 (p = 0.0244, T = −3.56) | 0.478 (p = 1, T = −1.66) |
| Fm | 0.374 | 0.338 (p = 0.23, T = −2.65) | 0.347 (p = 1, T = −2.04) | 0.345 (p = 1, T = −1.33) |
| L-CST | 0.535 | 0.5192 (p = 1, T = −1.23) | 0.523 (p = 1, T = −1.45) | 0.524 (p = 1, T = −0.56) |
| R-CST | 0.548 | 0.5305 (p = 1, T = −1.62) | 0.524 (p = 0.30, T = −2.57) | 0.495 (p = 1, T = −2.09) |
| L-CCG | 0.422 | 0.364 (p = 0.14, T = −2.81) | 0.354 (p = 0.87, T = −2.12) | 0.343 (p = 1, T = −1.15) |
| R-CCG | 0.360 | 0.323 (p = 0.93, T = −2.06) | 0.326 (p = 1, T = −1.11) | 0.343 (p = 1, T = 0.17) |
| L-CH | 0.358 | 0.338 (p = 0.14, T = −0.43) | 0.323 (p = 0.16, T = −2.84) | 0.322 (p = 1, T = −1.17) |
| R-CH | 0.370 | 0.323 (p = 0.054, T = −3.18) | 0.327 (p = 0.33, T = −2.54) | 0.316 (p = 1, T = −1.64) |
| RESULTS FOR MD | ||||
| L-ILF | 1.03 | 1.26 (p = 0.0018, T = 4.30) | 1.15 (p = 0.0012, T = 4.61) | 1.16 (p = 0.34, T = 2.62) |
| R-ILF | 1.02 | 1.21 (p = 0.0183, T = 3.56) | 1.08 (p = 1, T = 2.02) | 1.09 (p = 1, T = 1.62) |
| L-SLF | 1.04 | 1.09 (p = 1, T = 1.11) | 1.11 (p = 0.0208, T = 3.61) | 1.16 (p = 0.14, T = 3.02) |
| R-SLF | 1.00 | 1.01 (p = 1, T = −0.32) | 1.05 (p = 0.075, T = 3.14) | 1.13 (p = 0.68, T = 2.30) |
| L-TP-SLF | 1.06 | 1.10 (p = 1, T = 1.56) | 1.13 (p = 0.81, T = 2.15) | 1.17 (p = 1, T = 2.07) |
| R-TP-SLF | 1.05 | 1.09 (p = 1, T = 1.69) | 1.09 (p = 0.012, T = 2.95) | 1.14 (p = 0.0259, T = 3.76) |
| L-UF | 1.09 | 1.54 (p = 6.08e−06, T = 5.98) | 1.23 (p = 0.33, T = 2.54) | 1.30 (p = 0.0067, T = 4.34) |
| R-UF | 1.08 | 1.41 (p = 0.022, T = 3.49) | 1.15 (p = 1, T = 1.58) | 1.22 (p = 0.45, T = 2.49) |
| L-IFOF | 1.13 | 1.19 (p = 1, T = 1.41) | 1.21 (p = 0.0236, T = 3.57) | 1.21 (p = 0.82, T = 2.20) |
| R-IFOF | 1.08 | 1.15 (p = 0.71, T = 2.19) | 1.14 (p = 0.705, T = 2.22) | 1.14 (p = 1, T = 1.87) |
| L-ATR | 1.02 | 1.20 (p = 0.78, T = 2.14) | 1.20 (p = 0.0043, T = 4.17) | 1.32 (p = 0.0143, T = 4.01) |
| R-ATR | 1.04 | 1.23 (p = 0.26, T = 2.60) | 1.21 (p = 0.0183, T = 3.66) | 1.33 (p = 0.25, T = 2.76) |
| FM | 1.29 | 1.33 (p = 1, T = 0.65) | 1.42 (p = 0.07, T = 3.16) | 1.39 (p = 1, T = 1.28) |
| Fm | 1.08 | 1.08 (p = 1, T = −0.45) | 1.16 (p = 0.409, T = 2.46) | 1.21 (p = 0.26, T = 2.74) |
| L-CST | 1.16 | 1.23 (p = 1, T = 0.58) | 1.22 (p = 0.507, T = 2.36) | 1.01 (p = 1, T = 1.26) |
| R-CST | 1.16 | 1.15 (p = 1, T = −0.34) | 1.19 (p = 1, T = 1.19) | 2.41 (p = 1, T = 1.35) |
| L-CCG | 1.06 | 1.06 (p = 1, T = −0.12) | 1.09 (p = 1, T = 1.66) | 1.12 (p = 1, T = 2.06) |
| R-CCG | 0.975 | 0.990 (p = 1, T = −0.03) | 1.02 (p = 0.319, T = 2.56) | 1.05 (p = 1, T = 1.83) |
| L-CH | 1.03 | 1.21 (p = 1, T = 1.81) | 1.17 (p = 0.064, T = 3.20) | 1.23 (p = 0.077, T = 3.29) |
| R-CH | 1.04 | 1.17 (p = 0.82, T = 2.12) | 1.07 (p = 1, T = 0.52) | 1.14 (p = 1, 1, T = 1.77) |
Mean DTI metric, Bonferroni corrected p-values and T values are displayed. Mean diffusivity values are measured in mm2/s x 10–3.
L, left; R, right; ILF, Inferior Longitudinal Fasciculus; SLF, Superior Longitudinal Fasciculus; TP-SLF, Temporal Part of the SLF; UF, Uncinate Fasciculus; IFOF, Inferior Fronto-Occipital Fasciculus; ATR, anterior thalamic radiations; CST, Corticospinal Tract; CCG, Cingulum (Cingulate Gyrus); CH, Cingulum (Hippocampus); FM, Forceps Major; Fm, Forceps minor. Significant p-values are indicated in bold.