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. 2018 Jul 18;27(8):1476–1490. doi: 10.1002/pro.3441

Figure 1.

Figure 1

(A) A schematic illustration for the numenclature of granulin modules in zebrafish progranulins Aa, Ab, 1 and 2 as compared to human progranulin. Human P, G, F, B, A, C, D, and E identify granulin modules that appear sequentially in the human progranulin gene.7 (B) Sequence alignment of progranulin clones used in this study. Granulin modules 5 and 6 are missing from the partial clone, progranulin Aa, of zebrafish progranulin A. Progranulin Ab, on the other hand, is a full‐length clone spanning the entire sequence of zebrafish progranulin B.16 Both zebrafish granulin AaG and human granulin G have 10 cysteine residues instead of the canonical 12 cysteines for a GEM repeat [Fig. 1(A)] with a pair of cysteine residues missing (replaced) in two (the first and the third) of the four characteristic CC or double‐cysteine repeats.