Figure 7.

Three‐dimensional structure of AaE showing structural subdomains and critical/packing interactions among selected residues. (A) Backbone superposition of a set of converged structures of AaE calculated using NOE distances, dihedral angle and hydrogen‐bonding constraints. (B) Superposition of a set of refined structures of AaE after inclusion of residual (long‐range) dipolar coupling constants. Subdomain flexibility is still discernable, especially when the structure models are superimposed using the backbone atoms of the C‐terminal subdomain. (C) A ribbon diagram of the refined 3D structure of AaE rendered using the set of structures shown in (B). Three unique residues, Phe8, Pro18, and Trp24 are shown here with close‐contact side‐chain packing potentially stablizing the 3D structure of the N‐terminal subdomain.