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. 2018 Sep 3;7:154–169. doi: 10.1016/j.isci.2018.08.023

Figure 1.

Figure 1

Layers of Organismal Aging

Aging is a complex phenotype that occurs in multiple organ systems through partially distinct mechanisms. Within a given organ system aging occurs both within the cell and in the extracellular space. Our review focuses on the causes of aging within the cell.