Table 2. . IC₅₀¹, LC₅₀² and EC₅₀³ values of different compounds against trypanosomatids.

Inhibitor	Parasite	IC50	LC50	EC50
Trichostatin A	T. brucei (bloodstream)	–	–	6363 (4144–9770) μM – 48 h
Sulphonepiperazine analogue	T. brucei (bloodstream)	34 nM	–	1577 (1325–1878) μM – 48 h
Panobinostat	T. brucei (bloodstream)	–	–	2156 (1747–2662) μM – 48 h
Belinostat	T. brucei (bloodstream)	–	–	2751 (1917–3947) μM – 48 h
Tubastatin A	T. brucei (bloodstream)	–	–	–
	L. donovani (promastigote)	4.4 μg/ml – 72 h	–	–
	L. donovani (amastigote)	8.8 μg/ml – 72 h	–	–
	T. cruzi (amastigote)	0.5 (+/-)0.2 μM	–	–
	T. cruzi (epimastigote)	7 (+/-)0.51 μM	–	–
	T. cruzi (trypomastigote) 4°C	–	0.8 (+/-) 0.3 μM – 24 h	–
	T. cruzi (trypomastigote) 37°C	–	2.5 (+/-)1.1 μM – 24 h	–
KH-TFMDI	L. amazonesis (amastigote)	4735 μM – 24 h 2341 μM – 48 h 1976 μM – 72 h	–	–
	L. amazonesis (promastigote)	2367 μM – 24 h 2438 μM – 48 h 1976 μM – 72 h	–	–
	T. cruzi (epimastigote) Y strain	0.037 (+/- +0.016 mM – 72 h 0.126 (+/-) 0.025 mM 144 h	–	–
Nicotinamide	T. cruzi (epimastigote) Columbian strain	0.025 (+/- 0.001 mM – 72 h	–	–
	L. infantum (promastigote)	13.9 mM (+/-) 4.2 mM	–	–
	L. infantum (amastigote)	5.5 mM (+/-) 0.5 mM	–	–
Salermide	T. cruzi (amastigote)	2 μM – 24 h and 48 h	–	–
	L. donovani (promastigote)	25.7 μg/ml – 72 h	–	–
SAHA	L. donovani (amastigote)	> 40 μg/ml – 72 h	–	–

Information taken from [74,78,81–88,92,93].

EC₅₀: 50% cytotoxic concentration; IC₅₀: Half maximal inhibitory concentration; LC₅₀: Lethal concentration required to kill 50% of the population.