Fig. 3.

Individual differences in glial acetate metabolism (GAM) are related to the duration of hypoglycemia experienced during a 72-h fast. GAM, as measured by the percent enhancement of ¹³C bicarbonate (PE of HCO₃) following an acetate infusion, is both predictive of and responsive to subsequent fasting-induced hypoglycemia. a Relationship between glia acetate metabolism measured just prior to 72 h of fasting (day 0) and the subsequent exposure to hypoglycemia during the fast (percent time ≤ 70 mg/dL). A correlation analysis between these two variables demonstrated a robust positive relationship between GAM and the duration of hypoglycemia experienced during fasting (Pearson’s r² = 0.96, p = 0.004). b GAM measured following a 72-h fast (day 3) increase in a dose-dependent manner based on the magnitude of exposure to hypoglycemia during the fast (Pearson’s r² = 0.94, p = 0.007)