Table 3.
Numbers, rates and risks of adverse neurodevelopmental outcomes
| Total number | Hypoglycemia N = 1500 | No hypoglycemia N = 99,560 | Logistic regression Reference group = No hypoglycemia | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Number | Rate/1000 | Number | Rate/1000 | Crude | Adjusteda | ||||
| OR | 95% CI | OR | 95% CI | ||||||
| Any neurological or neurodevelopmental outcome | 3371 | 77 | 51 | 3294 | 33 | 1.58 | 1.25–1.99 | 1.48 | 1.17–1.88 |
| Any developmental delay | 675 | 29 | 19 | 646 | 6.5 | 3.02 | 2.07–4.40 | 2.53 | 1.71–3.73 |
| Motor developmental delay | 393 | 12 | 8.0 | 381 | 3.8 | 2.10 | 1.18–3.74 | 1.91 | 1.06–3.44 |
| Cognitive developmental delay | 314 | 17 | 11 | 297 | 3.0 | 3.83 | 2.34–6.26 | 2.85 | 1.70–4.76 |
| Autism spectrum and attention-deficit/hyperactivity disorders | 313 | 7 | 4.7 | 306 | 3.1 | 1.52 | 0.72–3.22 | 1.04 | 0.48–2.24 |
| Tics and stereotypic behaviour | 100 | 2 | 1.3 | 98 | 1.0 | 1.36 | 0.34–5.50 | 1.43 | 0.35–5.87 |
| Epileptic seizures and febrile seizures | 2456 | 45 | 30 | 2411 | 24 | 1.25 | 0.92–1.68 | 1.23 | 0.91–1.67 |
Congenital malformations, inborn errors of metabolism, and maternal diabetes are excluded
aAdjusted for mode of delivery, birth weight for gestational age, gestational age, sex, Apgar score and birth year