Table 3.

Treatment by clinical paradigm

By comorbidity
Anxiety	Cognitive behavioral therapy, anxiolytics
POTS	Above maintenance fluids, supplemental NaCl, propranolol, exercise
Sleep deprivation	Sleep hygiene, melatonin 3–10 mg q.h.
Fatigue/limited stamina	Coenzyme Q10 10 mg/kg divided b.i.d. into 200–300 mg b.i.d.
–
By subgroup
Migraine-related	Antimigraine agents including triptans
Sato variant	Amitriptyline, short-acting ACE-inhibitors/β-blockers for acute hypertension
Mitochondrial dysfunction	Amitriptyline + coenzyme Q10 (± l-carnitine, riboflavin)
Catamenial	Low-estrogen birth control pills (90 day) or depo-medroxyprogesterone
By genotype
RYR2 mutation	Propranolol