Table 2. A List of Commercialized Perfusion Systems.

Organ	Company Device	Common Features	Unique Features	Clinical Trials Status
Heart	Organ Transport Systems Life Cradle [50,51]	• Safe organ storage • Maintains oxygen levels • Monitors Temperature • Oxygenates perfusion solution • Transportable	• Uses preservation solution • Hypothermic Perfusion (5°C)	Pre-clinical trials completed No clinical trials reported
	Paragonix SherpaPerfusion Cardiac Transport System [80]		• Uses preservation solution • Hypothermic perfusion (4-8°C) • Monitors ischemia time • Low pressure perfusion (4-6 mmHg) • Can communicate with mobile devices • Single-use, disposable system	No record of clinical trials
	Transmedics Organ Care System Heart [52,53,81]		• Uses donor blood + solution mix • Normothermic Perfusion • Monitors organ function. Such as aortic pressure, coronary flow, heart rate, blood temperature • Housing enables ultrasound assessment and blood sampling • Console is reusable, but perfusion set is one-time use	• NCT02323321 • NCT00855712
Lung	Organ Assist Lung Assist [82]	• Safe organ storage • Ventilates organ • Allows for oxygenation and deoxygenation of perfusate for evaluation of lungs	• Uses preservation solution • Temperature controllable: 10-38°C • Pumps output up to 20 mmHg and 5L/min	No record of clinical trial
	Transmedics Organ Care System Lung [51]		• Uses donor blood + solution mix • Normothermic Perfusion • Enables ultrasound assessment and blood sampling • Console is reusable, but perfusion set is one-time use • Transportable	• NCT03343535 • NCT01630434 • NCT01963780
	XVIVO Perfusion Xvivo Lung Perfusion System (XPS) and Disposable Lung Set (DLS) [83]		• Uses preservation solution • Temperature controllable 15-39°C • Monitors pO2 and pH of perfusate • Allows for X ray • XPS is reusable, but requires single use DLS	• NCT01365429
Kidney	Organ Recovery Systems LifePort Kidney Transporter [84]	• Safe organ storage • Uses preservation solution • Transportable	• Hypothermic perfusion (uses ice) • Monitors: temperature, flow rate, vascular resistance, and pressure • System is reusable, perfusion kit is single use	• NCT03024229 • NCT02876692 • NCT02826213 • NCT01731457
	Organ Assist Kidney Assist (Transport) [85]		• Temperature control 10-38°C • Transportable version only supports 0 - 4°C • Oxygenates solution • Outputs flow, temperature, and pressure readings • Pumps output up to 20 mmHg and 5L/min	http://cope-eu.com/work%20programme/trials.html
	Waters Medical Systems Wave or RM3 [59,60,86,87]		• Hypothermic perfusion (3-10°C) • Oxygenates solution • Outputs 0-250 mL/min flow • Monitors pressure, flow, temperature, and renal resistance • Control unit is reusable, cassette is disposable/single use • Can be connected to a network for online monitoring of data	• NCT02826213 • NCT01170910
Liver	Organ Recovery Systems LifePort Liver Transporter [88]	• Safe organ storage	• Uses preservation solution • Hypothermic perfusion • Monitors: temperature, flow rate, vascular resistance, and pressure • System is reusable, perfusion kit is single use • Small, lightweight, transportable	No record of clinical trials
	Organ Assist Liver Assist [89,90]		• Uses preservation solution • Temperature controllable 10-38°C • Oxygenates solution • Outputs flow, temperature, and pressure readings • Allows for sampling of perfusate and bile	• NCT01317342 • NCT02584283 • NCT03124641
	OrganOx Metra [63,64,91]		• Uses blood • Normothermic perfusion • Maintains oxygen in perfusion • Measures pO2, pCO2, pH, temperature, glucose, bile production • Console is reusable but has a sterile disposable portion for single use • Large, but transportable	• NCT02478151 • NCT03089840 • NCT02775162 • NCT02740608
	Transmedics Organ Care System Liver [65,66]		• Uses donor blood + solution mix • Normothermic Perfusion 34-37°C • Maintains oxygen in perfusion • Measures lactate in perfusate and bile production for evaluation • Enables ultrasound assessment and blood sampling • Console is reusable, but perfusion set is one-time use • Large but transportable	• NCT02522871