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Mouse and human naive and primed pluripotent stem cells. (Top left) Mouse naive embryonic stem (ES) cells; (top right) Mouse primed epiblast stem (EpiS) cells; (bottom left) putative human naive induced pluripotent stem (iPS) cells; (bottom right) human primed iPS cells. Mouse ES cells were grown in N2B27-2i/LIF conditions. Mouse EpiS cells and human iPS cells were grown in FGF-containing medium. Human naive iPS cells were grown in a modified 2i/LIF medium (ADLA, data unpublished).
