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. 2018 Mar 20;55(11):8473–8485. doi: 10.1007/s12035-018-0993-0

Fig. 1.

Fig. 1

Influence of SB-334867 (20 mg/kg, i.p.) on the acquisition of morphine-induced sensitization to locomotor activity. Experimental mice received five injections of morphine (10 mg/kg, i.p.) on the 1st, 4th, 7th, 10th, and 13th to develop sensitization and a subsequent injection of morphine (challenge dose, 10 mg/kg, i.p.) was done on the 20th day (mph-treated group). SB-334867 (20 mg/kg, i.p.) was administered 15 min before each morphine injection but not before the morphine challenge dose (mph + SB-334867). After each morphine injection, locomotor activity was measured for 60 min. The presented data represent means ± SD and are expressed as the number of counts. n = 8–12 mice per group; *P < 0.05, **P < 0.01 (Tukey’s test)